Sentence examples for fluctuating exposure from inspiring English sources

Consequently, the average concentration of a fluctuating exposure pattern is assumed to result in the same toxicity as the fluctuating exposure.

Further, it allows calculation of the time course of risk in response to fluctuating exposure concentrations.

Variation in sensitivity of different species and effect types spans several orders of magnitude, whereas the difference between the toxicity of the fluctuating exposure profiles and that of their corresponding average concentrations was less than 4-fold.

(53) We quantified the difference in toxicity of the fluctuating exposure patterns compared with the toxicity of their average concentrations.

Animal studies indicate substantial distribution of PFOA to the liver and kidneys (Vanden Heuvel et al. 1991), which suggests that two or more compartments may be necessary to describe the toxicokinetics of PFOA under fluctuating exposure conditions.

For the fluctuating exposure time series from the urban part of the catchment the factor was 46 and for the corresponding average concentration of 0.1187 nmol/L the factor was 62.

Third, we adjusted the models for season of blood sampling to (a) correct for within-year fluctuations in 25OHD concentrations and (b) to reduce the influence of other (unobserved) seasonally fluctuating exposures.

The aim was to identify a more standardised way to measure the influence of xenobiotics on the individual feeding rate of gammarids at a daily resolution to allow the investigation of effects from short-term and/or fluctuating exposures.

The time course of internal concentrations of the parent compounds and their biotransformation in G. pulex can be simulated for any exposure pattern, including pulsed or fluctuating exposures using the models and parameter values derived in this study (Table 2).

In other words, as the seasonally-fluctuating exposure changes over the year, the biological variable of interest responds in a linear fashion.

Because FOXM1B provides survival advantage, we believe that the fluctuating nicotine exposure in long-term tobacco users serves as a selection mechanism for oral cells with increased FOXM1B expression thereby increasing the risk of malignant transformation through subsequent genomic instability and accumulation of further oncogenic hits.