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We injected fluctuating currents into the cells to simulate natural membrane potential fluctuations driven by various input events.
As rising temperatures and fluctuating currents do their work, the tripod is set adrift.
He did not float his fictions on the erratic, fluctuating currents of the stream of consciousness, as did James Joyce and Virginia Woolf, the prime exponents of this kind of novel.
Fluctuating currents were generated assuming inputs from independent groups of excitatory and inhibitory cells [40].
We found that fluctuating currents, presented before or during the compound EPSC generally reduced spike time precision (Figure 5B).
Fluctuating currents were added to the input signal either during or just prior to EPSC stimulation (then ending with EPSP onset).
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(J_{ito i+1}), (sqrt{xi_{i}},dW_{i}/dt), (J t)) are the tunneling current density from well i to well (i+1), the corresponding zero-mean fluctuating current density, and the total current density, respectively.
To address this issue, a fluctuating current mimicking stochastic synaptic input was linearly added to the compound EPSCs (Figure 5A; cf. Methods).
The role of "synaptic" or "intrinsic" noise in spike timing was investigated by the injection of a fluctuating current in two different configurations: one during the 200 ms immediately preceding the synchronized compound EPSC onset (pre-noise case) and another, starting 200 ms before and continuing during the presentation of the EPSC (noise case) (Figure 5A).
On top of the fluctuating current we added a sequence of EPSC-shaped currents (sEPSC) with a fixed time course (see Sect. 2, Fig. 1) and varied their peak amplitude (the range of spike output rates in these experiments was 8 20 spikes/s).
The LIF model, while poor in predicting the spike caused by the background fluctuating current (e.g. GCF = 0.5 when the sEPSC is very small; see Fig. 2) is pretty good in predicting spikes that are driven by the input sEPSC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com