Exact(2)
The DCM is based on a rigorous free energy decomposition scheme representing structure as fluctuating constraint topologies.
While not specified here, S c (N nt, N hb ) is a linear function of γ env, δ nat, δ dis, and I t, where t denotes each of the three fluctuating constraint types (see Table 1) [19].
Similar(58)
The VPG averages the constraint density at the edge level, and it does distinguish between quenched, missing and fluctuating constraints.
Within the mDCM, there are two types of fluctuating constraints, which define the two-dimensional free energy landscape shown in Fig. 1a.
Since we wish to benchmark the VPG under worst case conditions, uniform probability is applied to all fluctuating constraints.
Fluctuating edges that model H-bonds, for example, are present in the network with probability, p. Assigning a probability to fluctuating constraints reflects the continual process of intramolecular interactions breaking and reforming within the molecular structure, where the interaction is present p fraction of the time.
The cost-effective and feasible distribution and reuse of water within the network is identified from the superstructure-based optimisation model, with which all the operational constraints and fluctuating operating characteristics for water-using operations are fully and simultaneously reflected.
The results show that the proposed approach is able to reach a design with the full satisfaction of fluctuating power demand and system constraints.
Crosslinking distance constraints come from fluctuating H-bonds, and possibly quenched disulfide bonds.
For each macrostate, the PG must be applied hundreds of times to ascertain a statistically meaningful average probability for the fluctuating distance constraints to be independent or redundant.
In the genes with elevated rate of promoter class switching, TATA box can be under reduced selective constraint, or subject to fluctuating positive selection [ 25].
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