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In this study, we sought to assess the contribution of eIF4E to fludarabine (FLU) resistance in primary chronic lymphocytic leukemia (CLL) lymphocytes as this nucleoside analog is used as a first-line treatment for the disease.
In the first case, unless no FLU resistance is present locally among any CG isolates, a clinician may be forced to generalize that all non-albicans species be treated as if they were FLU resistant.
In contrast, our results indicate that, albeit FLU does not affect eIF4E phosphorylation status, MNK inhibition can sensitize primary CLL samples to FLU, thus suggesting that basal phosphorylation of eIF4E (in contrast to drug-induced phosphorylation) contributes to FLU resistance in U-IgVH samples.
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Their efforts to persuade the agriculture ministry to co-operate over livestock-related threats to public health, such as bird flu, have encountered stubborn resistance.
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