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Ktrans depends on balance between capillary permeability and blood flow in the tissue of interest.
Ktrans (and kep) have both blood flow rate and permeability components as Gd-DTPA is not freely diffusible and their biological meaning is dependent on the balance between capillary permeability and blood flow in the tissue of interest.
Ktrans has both blood flow rate and permeability components (as Gd-DTPA is not freely diffusible) and its biological meaning is dependent on the balance between capillary permeability and blood flow in the tissue of interest (Tofts, 1997; Tofts et al, 1999).
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A consequence of reduced blood flow in the tissue is entrapment of the molecules delivered before electroporation of the tissue, providing longer exposure of the cells to the cytotoxic drugs, by preventing washout of the molecules from the tissue.
Subsequently, micro bubbles are carried into the imaging plane by blood flow in the tissue, thus allowing the derivation of various hemodynamic tissue parameters from the dynamics of the replenishment.
Pressure relief increases the blood flow in the tissue and thereby a lack of oxygen is avoided [ 12].
The recovery of blood flow in the tissue depends on structural and functional integrity and body temperature [ 37].
Myocardial RI is a complex response of the organism to the restoration of coronary blood flow in the ischaemic tissue and is an important component of ischaemia-reperfusion injury [ 14, 15].
a The pHIFU-on state allowed to heat-generation, vasodilation effect, and blood flow enhancement in the tissue, resulting in increasing vascular permeability of nanoparticles.
Yet, the possibility to enhance local blood flow in the tumoral tissue presents interest in view of enhancing drug delivery to the tumoral tissue.
We hypothesized that improvement of microcirculation due to redistribution of blood flow in the inflamed tissue by TEA would result in improved pancreatic microcirculatory conditions and outcome in SAP.
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