Due to limited number of imaging time-points and the study design, it was not possible to discern whether the observed elimination kinetics of Aβ are due to active reverse transport across the BBB or to the interstitial fluid bulk-flow clearance.
Koning and coworkers analyzed the effects of intermittent positive airway pressure (IPPV) and spontaneous ventilation on cardiac output, renal blood flow, creatinine clearance, and urinary electrolyte excretion and observed decreased renal blood flow and creatinine clearance during IPPV conditions that partially improved during spontaneous ventilation.
The erosion on surfaces, upper and lower ends and leading and trailing edges of guide vanes induces cross flow at clearance gaps, tip leakage at trailing edges and high friction on the surfaces, increasing hydraulic losses associated with flow.
Conclusion: In an experimental porcine model of refractory cardiac arrest treated by ECLS, a low-blood-flow strategy during the first six hours of resuscitation was associated with a decreased cerebral blood flow, lactate clearance and microcirculatory parameters despite a lower inflammatory response.
dERPF: effective renal plasma flow (PAH clearance).
Therapeutic doses increase renal blood flow, creatinine clearance, urinary flow, and excretion of sodium.
In Morelli's study, levosimendan led to an increase in gastric mucosal blood flow, creatinine clearance, and urinary output.
Among other effects, levosimendan increased gastric mucosal flow, creatinine clearance, and urinary output while it decreased lactate concentrations.
Data on urine flow, creatinine clearance, and fractional Na+ excretion refer to the first and second half of the experiment, respectively.
Renal blood flow and clearance function can remain impaired for a prolonged period of time after an episode of AKI, despite apparent normalization of sCr [ 31].
