Benzodiazepines present the risk of congenital malformations, and central nervous system abnormalities, respiratory depression, floppy infant syndrome, and potential neonatal withdrawal [7, 8].
CHN, an autosomal dominant or recessive disease (Table 1), is characterized by severe hypotonia ("floppy infant"), dysphagia, and respiratory insufficiency, usually occurring within the first year of life.
Their use by expectant mothers shortly before the delivery may result in a floppy infant syndrome, with the newborns suffering from hypotonia, hypothermia, lethargy, and breathing and feeding difficulties.
In the presence of a floppy infant, evaluation of signs of CNS involvement is essential but not always easy during the first year of life.
Neonatal epileptic seizures and floppy infant syndrome are two important symptoms that point to an involvement of defective GABAergic signaling in ZS pathogenesis.
The girl was a floppy infant with initial hypotonia progressing to hypertonia of the extremities and truncal hypotonia later in life.
The infant is typically a floppy baby with failure to thrive and severe respiratory distress.
Although a rare disease (MCT8 mutations have been reported in about 50 families all around the world), we illustrate the importance of excluding Allan-Herndon-Dudley syndrome in the evaluation of floppy male infants with development delay, without history of perinatal asphyxia.
Sometimes known as floppy baby syndrome, it's a leading genetic killer, hitting one in 8,000 infants and toddlers.
