Sentence examples for flipped base from inspiring English sources

Additional aspects of protein-DNA interaction that are analyzed by PDA include "running-into-protein" DNA (when the axis of a double-stranded DNA is blocked by a protein) and "flipped base" (if a base in a double-stranded DNA does not have a base-pairing partner and is in contact with protein).

We show that base flipping in Tn10 transposition is not a passive reaction in which a spontaneously flipped base is captured and retained by the protein.

This may be an indirect consequence of the base flipping defect in this mutant which would reduce the crucial interaction between the flipped base and the stacking tryptophan.

However, the role of the probe residue remained ambiguous, particularly whether it is actively involved in base flipping, or serves only to fill the space vacated by the flipped base.

To access lesion bases, AAG, like most glycosylases, uses the canonical nucleotide flipping mechanism wherein the nucleoside with the damaged base is flipped out of the double helix and into the active site while a protein residue intercalates the DNA, effectively substituting for the flipped base.

Many base flipping enzymes also have a wedge or probe residue that intercalates into the helix, filling the space vacated by the flipped base.

This is presumably related to the long-range relationships between the backbone moieties or direct interactions with the flipping base itself, as previously observed [17].

The research shows that the ranking of industries in terms of online ratings often flips based on whether reviews are left voluntarily or in response to an incentive.

Our research shows that the ranking of industries in terms of online ratings often flips based on whether reviews are left voluntarily or in response to an incentive.

First, a symbol position is selected for flipping based on the current symbol reliabilities.

All glycosylases share a common mode of action for damage recognition; they flip bases out of the DNA helix into a selective active site pocket, the architecture of which permits a sensitive detection of even minor base irregularities.