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Selected compounds were also evaluated for analgesic activity in the mouse-tail flick test.
The heat radiant tail flick test is commonly used to quantify nociception and pain levels.
This phenomenon was associated with delayed responses to the phasic, thermal stimulus induced by the tail flick test.
This led to the discovery of 24, which had an increased duration of action in the mouse tail flick test in comparison to the lead 1.
Behavioral tests (mirror chamber, actophotometer, tail flick test) and biochemical analysis (malondialdehyde level, nitrite, glutathione and catalase enzyme) were performed subsequently.
induced hyperalgesia in tail flick test, but it was prevented by co-injection of α,β-Me-ATP with suramin (120 μg/rat, i.t).
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The antinociceptive response was assessed by recording the latency in a tail-flick test.
The nociceptive threshold in diabetic and non-diabetic mice was measured in the tail-flick test.
In the mice tail-flick test, EMs (1, 5, 10 nmol/mouse, i.c.v).
In the tail-flick test, DAMGO (1 10 ng, intracerebroventricularly) produced a marked dose-dependent antinociception in non-diabetic mice.
A tail-flick test was performed and CSF dialysate was collected as the baseline-B value (day 0) before PTX (1 μg, i.t).
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