These results indicated that MPER is natively flexible, indicating that more than one structure is associated with neutralization and, at the same time, implying that multiple conformations of MPER immunogens may be favorable to the induction of bNAbs.
The nuclear Overhauser effect (nOe) data show that the FG-N are highly mobile and flexible, indicating no sequence-specific compaction, folding, or molten globule formation (Uversky, 2009; Theillet et al., 2014).
The residues connecting AS and ANK repeats (10 residues in total, 'GSLVPRGSGS') are flexible, indicating that the fusion of the two chains together does not introduce obvious conformational restraints to the complex.
The experimental and FE simulation results of the flexible element and the integral flexible structure indicate that the presented mechanical model is capable of capturing the linear behavior.
The flexible diodes indicate significant/slight performance dependence with compressive/tensile bending strains paralleled to or tensile/compressive strains perpendicular to diode current flow direction.
Results on the viscoelastic foams, as with the flexible foams, indicate two-phase morphology, contrary to the conventional wisdom in the industry that viscoelastic polyurethane foams are phase-mixed.
However, this hypothesis would require us to accept that LMP hominins were less technologically flexible than indicated by the African and Eurasian archaeological evidence (6, 33, 34).
Both RRMs of SNF are quite rigid, whereas the linker loop (96 140) is flexible as indicated by low {1H}-15N NOE values (Figure S3).
Residues 88 95 in RRM1 form an α-helix (αC) which is flexible, as indicated by the fact that {1H}-15N NOE values for residues in helix αC are significantly lower than those in the core regions of RRM1 (Figure S3).
The analysis of predicted coding sequences (CDSs) within the LF82 flexible genome indicated that this genome is close to the avian pathogenic strain APEC_01, meningitis-associated strain S88 and urinary-isolated strain UTI89 with regards to flexible genome and single nucleotide polymorphisms in various virulence factors.
Overall, the analysis of CDSs within the LF82 flexible genome indicated that this strain shared the highest percentages of common CDSs with strain APEC-01 isolated from lesions of chickens and turkeys clinically diagnosed with colibacillosis, followed by meningitis-associated E. coli strain S88 isolated from human cerebrospinal fluid, and by E. coli strain UTI89 isolated from human urine (Table 3).
