Sentence examples for flexible compounds from inspiring English sources
It is noteworthy that natural products exhibit a wide range of flexibility, from rigid conformationally constrained molecules to very flexible compounds.
The models obtained from rigid and flexible compounds were employed together to obtain a conservative method for predictions.
Conformationally flexible compounds can, however, combine high permeability and solubility, properties that are keys for cell permeability and intestinal absorption.
Thus, one can productively tackle the computational conformational search of larger flexible compounds for drug discovery, including macrocycles.
However, few studies have tested in details the sampling of larger more flexible compounds, which are also relevant to drug discovery, including therapeutic peptides, macrocycles, and inhibitors of protein protein interactions.
This limit is more than adequate for small or inflexible structures but for flexible compounds this limitation is of concern.
The objective is to constrain an originally flexible compound and to impose precise conformations and configurations.
This paper proposes a novel flexible compound pressure sensor array for measuring radial artery pulse wave to overcome the problems mentioned above.
An economical and flexible compound fabric was prepared using Kevlar fabric and glass fabrics as well as recycled Kevlar/Nylon/low-Tm polyester nonwovens via needle-punching and thermal-bonding processes.
A dataset of 55 compounds with inhibitory activity against Leishmania donovani axenic amastigotes and Leishmania amazonensis intracellular parasites was examined through three-dimensional quantitative structure activity relationship modeling employing molecular descriptors from both rigid and flexible compound alignments.
The results show that the flexible compound pressure sensor array not only reflects depth information of radial artery pulse wave under a wide range of static pressures, but also has good repeatability and anti-interference performance.
