Sentence examples for flexible alignment from inspiring English sources
Since these representative pairs involve domain movements, rigid alignment methods would not be able to align these pairs effectively, while flexible alignment methods will be able to introduce hinges and align the pairs more effectively.
Flexible alignment is correctly seen as an important innovation in aligning protein structures, however our results demonstrate that it is not a panacea: introducing flexibility into alignments greatly enlarges the search space, exacerbating problems in generating high quality alignments for more distantly related proteins.
The two main flexible alignment methods, FlexProt [ 11] and FATCAT [ 12], work by clustering (chaining) aligned fragment pairs (AFPs) and allowing flexibility while chaining, by introducing hinges (twists).
Molecular modeling study including flexible alignment; electrostatic, hydrophobic mappings; and pharmacophore prediction were performed.
For example, we did not find flexible alignment of Ai's tapping to other auditory rhythms whereas humans can intentionally synchronize their tapping to various rates in a rage between 200 ms to 1800 ms1800
A set of seven novel N-substituted 2-anilinophenylacetamides were designed by pharmacophore generation and using flexible alignment module of MOE software.
Although, compared with the case with DaliLite, greater values of both sensitivity and precision, except for the quite low (5 10%) range of sequence identity, were observed using Fr-TM-align, which allows flexible alignments, for all matrices and methods, overall trends were preserved in both cases.
To assess the alignment quality, we compared sequence alignments with the structural alignments generated by Fr-TM-align (Pandit and Skolnick, 2008), which allows flexible alignments, and DaliLite (ver. 3.3) (Holm et al., 2008) as reference alignments.
The method is based on flexible alignments using a new design paradigm and scoring system that aims to reduce the molecular weight of the compound and preferentially lead to drug like molecules.
Here we introduce Geomfinder, an intuitive, flexible, alignment-free and ligand-independent web server for detailed estimation of similarities between all pairs of 3D patterns detected in any two given protein structures.
Here we introduce Geomfinder, an intuitive, flexible, alignment-free and ligand-independent web server for an exhaustive searching of similarities among pairs of 3D patterns detected in two given protein structures (X-ray or homology models).
