Sentence examples for flexibility structure from inspiring English sources
Optimally, and especially for protein kinases, a broad range of crystal structures should be obtained to characterize target flexibility, structure modulation via co-factor binding or posttranslational modification, ligand induced conformational changes, and off-target complex structures for selectivity optimization.
This possibility is consistent with our main point: a WW domain mutation (I28A) at the domain interface can perturb the conformational sampling of the PPIase domain in such a way that it alters local flexibility, structure, or both.
There are several similarities between recombinant PrP fragments and PrPSc, including structural flexibility, structure-dependent in vitro cytotoxicity, and, in particular experimental conditions, infectivity, supporting the hypothesis that in TSE patient brains, hPrP90-231-like fragments might have a causative role in neuronal apoptosis.
We develop a distribution-free model to evaluate the performance of process flexibility structures when only the mean and partial expectation of the demand are known.
The objective is to identify preferred flexibility structures in service or manufacturing systems, when demand is random and capacity is finite.
While the presence of rotatable bonds on the GO ligand structure imparted flexibility, structures of chitinases were considered to be rigid for docking.
Meanwhile, Virgin America's Payson says a flexible model will help you meet your objectives and stay responsive, he balances flexibility with structure by working in three-month cycles.
One of them is to give his two key players, Latrell Sprewell and Allan Houston, more flexibility, less structure.
Incorporation of α-helix flexibility into structure refinement and design is discussed.
In addition, the Primary Care track offers PGY2 residents valuable flexibility to structure some of their elective time for international clinical and/or research electives.
