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Collapsing the free energy landscape in constraint space onto the global flexibility order parameter makes a direct connection between free energy of a protein and its flexibility.
At times it is convenient to express the free energy as a function of a one-dimensional flexibility order parameter, θ(N nt, N hb ).
From simple geometric considerations, and the construct of the mDCM, the path along the global flexibility order parameter must always cross the saddle.
We call this quantity the global flexibility order parameter, defined by θ' (N nt, N hb ) ≡ ⟨I dis (N nt, N hb )⟩/n, where n is the number of residues in the protein.
Nature shows us that all three phases of water can be present at once, Chialvo says: rain in clouds, frozen lakes, the vapor of a hot humid summer day, all inter-depending in the same system containing structure and flexibility, order and disorder.
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Most existing L2-based filter design techniques utilize this flexibility in order to improve their performance.
"They also need speed, agility and flexibility in order to be able to pay out as soon as the wheel stops on the table.
The American Eagle purchase agreement for regional jets from Embraer provides the flexibility to order the smaller jets with 50, 37 or, possibly, 44 seats, the airline said.
They insist (as do the sugar companies) that all they really want is flexibility in order to avoid endless lawsuits if they miss the 2006 deadline.
Georgia has said it could agree to one or the other, but not both, saying it will need flexibility in order to provide the water that Atlanta needs.
Employers and unions wanted some flexibility, in order to attract desired employees, so the Administration permitted increases in health-insurance benefits, and made them tax-exempt.
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