The WEF, IMD, and Fraser all aggregate de facto data, such as survey questions on the flexibility of regulations, with de jure information, such as weeks of advance notice and severance pay, also adding aggregated indices of the World Bank and, in some instances, "hard" statistical data.
Such "new governance" mechanisms are designed to increase flexibility, improve participation, foster experimentation and deliberation, and accommodate regulation by multiple levels of government.
Alternative UTRs are thus a possible mechanism to ensure a necessary flexibility of gene regulation by miRNAs.
The decreasing complexity observed along the optimization process suggest a tradeoff between the coherence of the periodic activity and the flexibility of its regulation.
DNA methylation and histone modification have been revealed as hallmarks that establish the functional status of chromatin domains [ 16] and confer the flexibility of transcriptional regulation necessary for plant development and adaptive responses to the environment [ 17- 19].
The diversity and flexibility of transcriptional regulation by bZIP TFs can at least partially be attributed to their potential to form variable dimer combinations, which bind to different consensus target sites (Deppmann et al., 2006; Tsukada et al., 2011).
Paralogs may yield increased metabolic flux, or may provide additional flexibility in terms of regulation, compertmentalization, and biochemical properties (deoxyxylulose phosphate synthase, and possibly ABC transporters for hydrocarbon export).
Reik, W. Stability and flexibility of epigenetic gene regulation in mammalian development.
The similarly phrased WEF survey question on ease of hiring and firing and the IMD survey questions on flexibility of labour market regulation correlate rather well (0.78).
A rigid determination of the type of immune response, without retaining flexibility or regulation of an activated T cell and an appreciation of the changing environment along the adaptive immune response, can result, on the one hand, in an often lethal organ failure associated with the site of infection, or, on the other hand, promotion of autoimmunity that follows an infection.
