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A major flaw of this study is that it was not shown whether or not the anti-AFP antibody was actually attached to the QD.
The main flaw of this study was the use of the solvent dimethylsulfoxide (0.15 %) above the OECD-recommended concentration in test controls and treatments, and the relatively high concentration of 4%% formaldehyde as a disinfectant for fish eggs.
A flaw of this study was that heterogeneous study population included women having more than one compartment repair and those with and without anti-incontinence sling surgery.
The main flaw of this study was the lack of power to detect differences between the two groups because of the small sample size, leading to wide CIs around the risk ratios.
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The difficulties in resolving these biases are potential flaws of this study.
Although designed as an investigational study, one of the major flaws of this study is the observational design.
The methodological flaws of this study (exclusion of a substantial number of patients after randomization limiting the benefits of randomization) should have been specifically highlighted in my opinion.
Since the publication of this study, several methodological flaws of this study have been discussed, in particular the statistical analysis, and the interpretation of the results are not undisputed (Alford et al. 2012; Verster et al. 2012).
Self-selection can be seen as a flaw of the study, but may also (particularly because of this high level of education in our sample) actually add weight to our findings, given the likelihood that participants may be comparatively well informed about ADs.
Third, the MoCA scores of the healthy controls in this study were abnormal, which is an inherent flaw of the study.
A common flaw of those studies is a lack of a clear definition for SDD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com