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However, protein protein interactions have long been viewed as high-risk targets due to the fact that proteins generally offer relatively large and flat interacting surfaces that are not readily disturbed by small-molecule drugs (Arkin and Wells, 2004).
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The power spectrum of noise due to an isolated flat plate airfoil interacting with incident turbulence is predicted, and its result is successfully validated against Amiet׳s analytic model (Amiet, 1975) [4].
This paper investigates the modal acoustic power (MAP) generated by a cascade of flat-plate airfoils interacting with homogeneous, isotropic turbulence.
Considering both the structural data and results of site-directed mutagenesis obtained here, together with the previous mutagenesis study of Ca2+-coordinating residues Asp94 and Glu99, which severely hampered the ice binding [23], we propose that the ice-binding site of hAFP consists of Asp94, Thr96, Thr98, and Glu99 that form a relatively flat surface to interact with ice (Figure 8AB).
The native complexes of these entries have either convex and concave surfaces or almost flat surfaces in the interacting regions.
Owing to its ability to interact with flat aromatic compounds, hypericin may potentially be used as an interceptor molecule.
Near the guitar are the things he uses for manipulating the sound of the guitar or interacting with it: flat objects of various weights and hardnesses, a couple of effects pedals, a small electric fan, a wad of steel wool, a small radio, an iPod, a sound mixer.
A finite element method (FEM) simulation was used to study the elastic behaviour of an Ag dumbbell structure interacting with a flat substrate (more details in Additional file 1: Figure S4).
Discrete element method has been used to simulate the behavior of particles interacting with a flat plate in order to define a relationship between shear-normal impact energy and wear rate during mechanical erosion.
2D averaging of images of negatively stained filaments shows double protofilaments interacting with their flat sides, which coincides with other, double-helical actin-like protein filaments (Popp et al., 2010a, 2010c, 2012, 2012; Salje et al., 2011; Gayathri et al., 2013).
Considering interacting and non-interacting scenario of GDE with dark matter in a spatially non-flat universe, we investigate the cosmological implications of this model in detail.
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