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This program allows the user to create the desired flat beam profile by providing the best scatterer thickness and an appropriate beam deflection angle, where both are fundamental parameters in the flat dose profile generation.
A mathematical algorithm was developed, using the simulated pristine dose profiles as its input, to calculate the weight of each pristine peak, reproduce the SOBP, and finally generate a flat dose distribution.
Ribavarin is a purine nucleoside analogue and can be given weight based or a flat dose.
The median total flat dose received by patients in cycle 1 was 56 000 mg.
No correlation was found with body surface area suggesting possible use of flat dose regimen for next trials [ 99, 100].
Sirolimus was administered at a single oral flat dose of 5 mg per day continuously in an outpatient setting.
Similar(34)
Vision alone is unlikely to explain the flat dose-response of C. vestalis.
The flat dose-response curve and wide therapeutic index of SSRIs argue against a strong relationship between plasma levels and clinical response [34] and there is little evidence regarding how plasma levels of citalopram influence clinical efficacy [35].
However, C. vestalis parasitoids showed a flat dose-response relation; they preferred to land on plants with DBM damage, yet did not discriminate between contrasting levels of plant damage (Figure 1b).
The dose-response relationship for high-dose LSS data (above 1.5 Sv) is more consistent with a plateau shape (flat, dose-independent) rather than a linear increase.
Further, indirect evidence for a possible biphasic effect on bone comes from research into possible angiogenesis effects of statins[ 31], and there seems to be quite a flat dose-response curve[ 32].
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