Sentence examples for flat atypical from inspiring English sources

However, additional morphologic, immunophenotypic and genetic studies are needed to better define the relationships between these flat atypical lesions to DCIS and invasive breast cancer.

Other authors have also noted an association between various flat atypical lesions and DCIS and/or invasive carcinoma [ 4, 9, 10].

In a recent genetic study of 13 cases of the flat atypical lesion designated 'DIN-flat monomorphic type', Moinfar and colleagues found that 70% showed loss of heterozygosity at one or more of the eight loci evaluated [ 8].

Other investigators have also noted that the cells comprising some flat atypical lesions are cytologically similar to or identical to the cells comprising some forms of DCIS or to the cells comprising the glands of tubular carcinoma [ 6, 8, 10, 11, 18].

Pancreatic ductal adenocarcinoma (PDAC), the predominant form of pancreatic cancer, develops via acinar-ductal metaplasia (ADM) and neoplastic precursor lesions, such as pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasia (IPMN), mucinous cystic neoplasia and atypical flat lesions (AFLs; Morris et al, 2010; Aichler et al, 2012).

On flat-mount this "atypical" vasculature, was less fluorescent and the tubes were considerably more dilated and less branched when compared to the other retinal blood vessels (Figure 7A).

Development of malignant invasive breast carcinoma is considered as a continuous process from normal epithelium, flat epithelial atypia (FEA), atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) to invasive ductal carcinoma.

Oyama and colleagues studied 21 cases of the flat lesion they termed "atypical cystic lobules" [ 3], and found these lesions to be more common in specimens containing DCIS than in specimens without DCIS (36% versus 3%).

DYX1C1: Dyslexia susceptibility 1 candidate 1; IHC: Immunohistochemistry; ERα: Estrogen receptor alpha; PR: Progesterone receptor; qRT-PCR: Quantitative reverse transcriptase polymerase chain reaction; DCIS: Ductal carcinoma in situ; FEA: Flat epithelial atypia; ADH: Atypical ductal hyperplasia.

Histologically, the human cells were slightly larger than the murine luminal cells, but there was no evidence of the premalignant changes of the sort usually observed in flat epithelial atypia or atypical ductal hyperplasia [ 29].

The initial version as proposed by Tavassoli (1998) was subsequently modified as follows: DIN 1a: flat epithelial atypia; DIN 1b: atypical ductal hyperplasia (ADH); DIN 1c: DCIS grade 1 (low grade); DIN2: DCIS grade 2 (intermediate grade); DIN3: DCIS grade 3 (high grade).