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In these calculations, the thresholds c of the continuous biomarker were chosen to demonstrate various possibilities for outcome prediction including fixed sensitivity, fixed specificity, and balanced sensitivity and specificity.
True, Douglas Stein's setting -- a red dirt hill, complete with rocks, holes and bogs -- and Anita Yavich's silent-clown tramp costume have a fixed specificity.
This study asks which index can detect significant deterioration earliest, for a fixed specificity.
A further optimization strategy involves using spaced k-words, which improve the sensitivity for a fixed specificity [ 39].
On the other hand, in non-diabetic men, for MetSATPIII the optimal HOMA-IR cut-off was 1.85 (sensitivity, 0.78; specificity, 0.57) when YI criteria were used and 2.27 (sensitivity, 0.61) with fixed specificity criteria.
Splitting sentinel data into separate geographic-based streams and monitoring all 8 streams for 2 or 3 simultaneous aberrations provided substantial improvements in AUWROC and also in timeliness for a fixed specificity when compared with monitoring aggregated data or any single data stream.
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At fixed specificities, the sensitivities of each ITDS varied.
We also determined sensitivities and CSF cut-off values at fixed specificities of 90% and 955 %.
Similarly, we evaluated sensitivity distributions by fixing specificity.
When comparing two tests, it is a good practice to select cut-offs that fix specificity at a particular level for both tests, which allows test sensitivities to be compared at equivalent specificities.
The repercussions of fixing specificity at 90 95 % on sensitivity have to be interpreted more cautiously: given the relatively low number of true positives, a change in classification of an individual case from positive to negative may lead to a disproportionately large decrease in sensitivity.
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