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The STAMPEDE subjects (11 18, 21, & 23) with the group 1 miRNA expression profile have provisional diagnoses of chronic obstructive pulmonary disease, fixed obstruction, airway hyperreactivity, air trapping, asthma, low DLCO (2 subjects), and constrictive bronchiolitis.
Increased pulmonary blood flow can be detrimental in case of obstructed pulmonary venous flow, by causing worsening pulmonary edema in the face of a fixed obstruction [6].
Subjects with severe established fixed obstruction were excluded.
Nevertheless, the flow-volume curve typically displayed localized fixed obstruction of central airways.
Previous work has shown that in patients with similar levels of fixed obstruction, history can distinguish asthma and COPD as separate airway pathologies [ 25, 26].
In individuals who already have asthma, endotoxin may also contribute to airway remodeling and fixed obstruction in the airways (Reed and Milton 2001).
Similar(43)
Nasal surgery consists of several procedures that can fix obstructions or deformities like deviated septums.
Furthermore, our results suggest that both small and large airways obstruction contribute independently to fixed airways obstruction in severe asthma.
These results suggest that both small and large airways obstruction contribute independently to fixed airways obstruction in severe asthma.
The possibility of the presence of localized airway obstruction was raised when the flow-volume curve suggesting fixed airway obstruction, was obtained.
The fixed airways obstruction phenotype occurs in a small proportion of patients who experience irreversible airways obstruction despite inhaled corticosteroids or bronchodilators [ 5, 6].
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