71– 74 Other uncommon reported doxycycline-induced skin eruptions include fixed drug eruption, acute generalized exanthematous pustular eruption, and Sweet's syndrome.
8 In the study performed by Souissi et al in 2007, the most common cutaneous clinical manifestations were maculopapular eruptions followed by fixed drug eruptions, and antibiotics and NSAIDs were the most commonly purported agents.
In patients with a diagnosis of fixed drug eruption induced by trimethoprim-sulfamethoxazole (34 patients), most lesions were present in the genital area (18 patients).
In cases of fixed drug eruption (FDE), skin lesions recur at the same sites after repeated exposure in 1-2 weeks, and the interval between reexposure and eruption appearance is usually 24 h.
In the group taking NSAIDs (nine patients), one patient had a fixed drug eruption on the lip, one patient had it on the genital area, and two patients had lesions on both the lip and genital area.
In patients with a diagnosis of fixed drug eruption induced by trimethoprim-sulfamethoxazole, most lesions were seen in the genital area, whereas in the group taking NSAIDs, most lesions were seen on the hands and feet.
Acute urticaria was the most common clinical presentation (59.2%) followed by fixed drug eruptions (18.5%), and maculopapular eruptions (14.9%).
It induces maculopapular rashes as well as SJS, TEN, exfoliative dermatitis and fixed drug eruptions.
The most common forms of cutaneous ADRs in order of frequency were acute urticaria, fixed drug eruptions, and maculopapular rashes.
The most common forms of cutaneous adverse drug reactions were found to be acute urticaria, fixed drug eruptions, and maculopapular rashes.
