Your English writing platform
Discover LudwigExact(11)
The original Emond et al. (2004) model is designated the fixed elimination model.
When the model assumes a fixed elimination of TCDD, t1/2 increases with dose, due to hepatic sequestration.
In epidemiologic studies, exposure assessments of 2,3,7,8-tetrachlorodibenzo 2,3,7,8-tetrachlorodibenzofixed elimination rate.
The use of an inducible elimination provides better fits to the experimental data of Santostefano et al. (1998) compared with the fixed elimination model.
In the fixed elimination model, 15 parameters have normalized sensitivity coefficients greater than ±2% at the low dose, and 11 parameters at the high dose.
The low-dose exposure in the fixed elimination model is uniquely sensitive to parameters related to the distribution of TCDD such as cardiac output, BW, blood flow, and partitioning to liver and fat.
Similar(49)
Execution involves sequential optimization of the models, fixed model elimination rules to remove failed models and failed MC simulations increasing both parameter reliability and accuracy (d'Auvergne and Gooley, 2006) and a final run whereby Akaike's Information Criterion (AIC) model selection is used to judge statistical significance (Akaike, 1973; d'Auvergne and Gooley, 2003).
The influence of KBILE_LI, BMI, CYP1A2 induction, and TCDD binding to CYP1A2 on the terminal elimination t1/2 of TCDD was examined using the fixed and inducible elimination models.
This is a struggle — the battle between farmers bent on survival and a landscape seemingly fixed on their elimination — in which tools have proved decisive.
The K e (fixed speed of elimination 1/h) was calculated by a computer program, and the T0,5 (time of biological half-life in h) was determined by dividing 0.693 by K e.
Bodyweight was tested as an allometric function on the volume of distribution (power fixed to 1), elimination and inter-compartmental clearance parameters (power fixed to either 3/4 or 2/3) to correct for differences in bodyweight between the pregnancy and post-partum visit.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com