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The choice of a fixed alignment estimate is indicated in column  if applicable.
The number of homologous sites depends on the method used to compute the fixed alignment.
We have previously combined statistical alignment and phylogenetic footprinting to detect conserved functional elements without assuming a fixed alignment.
Note that the fixed alignment is not required in the proposed method, while the method (M2) requires fixed alignments.
To assess alignment ambiguity we compare the posterior topology distribution for the full joint model to the distribution generated under models restricted to a fixed alignment.
All sequences then range in length from 57 to 69 nucleotides with an alignment length of 69 nucleotides independent of the method used to compute the fixed alignment.
Similar(43)
In the outer level of the model, we optimize the horizontal alignment and in the inner level of the model a vertical alignment optimization problem considering earthwork allocation is solved for a fixed horizontal alignment.
Orthodontic treatment consisted in upper and lower first premolar extractions; anchorage and 0.022" Roth fixed appliances alignment and leveling was performed with the following archwire sequence: 0.014 -0.018" NiTi.
In contrast to traditional methods of phylogeny estimation that arbitrarily fix the alignment, we treat the alignment A as a random variable, leading to the probability expression P Y, A, τ, T, Θ, Λ) = P(Y| A, τ, T, Θ) × P(A| τ, T, Λ) × P τ, T) × P × P. (1) The substitution likelihood P(Y| A, τ, T, Θ) and the priors P τ, T) and P occur in traditional Bayesian models that fix the alignment.
Simulated alignments allowed us to fix the alignment length, the evolutionary model, and its parameters.
As an alternative, we propose to fix the alignment between sequences in the pruned subtree and the alignment between sequences in the remainder, but allow the alignment between the two groups of sequences to vary.
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