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Application of the GrowMatch to fix this inconsistency suggests suppressing reaction G6PDH2er (glucose-6-phosphate dehydrogenase [endoplasmic reticulum]) which is identical to the reaction catalyzed by Zwf1p in the cytosol (i.e., G6PDH2).
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We cleaned all data at least twice before generating the final database by requesting the fire departments to fix the inconsistency in the data.
The modeler chooses when to fix the inconsistency.
(2) If the two genes are coding for two (or more) different reactions that are all blocked because of the same root no-consumption metabolite then exploring the addition of the (common) downstream, or the corresponding root problem metabolite, to the biomass equation as a reactant may fix the inconsistency.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com