Sentence examples for fix expression from inspiring English sources

Concomitantly with the decrease in anti-FIX Abs, FIX expression gradually rose, reaching more than 50% of normal levels at 16 weeks after gene therapy, which is in line with the expected reconstitution for the administered LV dose (Fig 2C,D).

IDLV-mediated and hepatocyte-targeted coagulation factor IX (FIX) expression prevented the induction of neutralizing antibodies to FIX even after antigen rechallenge in hemophilia B mice and accounted for relatively prolonged therapeutic FIX expression levels.

The molar excess (30 60 fold) of anti-FIX IgG produced in the mice as compared to the FIX output observed after Abs reversal makes it unlikely that FIX expression per se can saturate circulating Abs and overcome their effect.

Hemophilia B patients who develop transient transaminitis and loss of FIX protein may be stabilized with the immune-suppressive (IS) drug prednisolone, but do not all recover lost FIX expression, whereas some patients fail to respond to IS.

Here, we extend this model to an immune-competent host where Cap-CD8 transfer to AAV2-F9-treated mice significantly reduced circulating and hepatocyte FIX expression.

Subsequent translational studies indicated that therapeutic FIX expression levels could be attained reaching 20 35% of normal levels after AAV-based liver-directed gene therapy in cynomolgus macaques.

Mr. Jones, with his smoothly shaved head and permanently fixed expression of amusement, has been an unmistakable dandy since the early '80s heyday of the Blitz nightclub.

Copyright only applies to fixed expressions, not to the ideas that may make up a fixed expression.

However, in the model with completely fixed expression, speciation probabilities were lower than in others.

Although many S/T-correlated genes exhibited fixed expression during the breeding process (Table 6), little improvement was observed for this trait (Table 4).

Gestures go a long way toward compensating for the sculpted faces' fixed expressions.