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German conservator Christian Eckmann, who will oversee the mask's restoration, admitted at the press conference that epoxy is "not the best solution to fix artefacts", according to Ahram Online.
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The publicly available data were pre-processed as described in Smith et al. (2013), which included correction for spatial distortions and head motion, registration to the T1 weighted structural image, resampling to 2 mm Montreal Neurological Institute (MNI) space, global intensity normalization, high-pass filtering with a cut-off at 2000s, and the FIX artefact removal procedure.
"I fix".
Quick fix.
Since, in our experience, and that of others, microsatellite instability is rare in breast cancers, we suspected that the multiple (35) rounds of PCR amplification required to obtain sufficient product from fixed tissue sections were generating artefacts.
All employed constraints were fixed, to avoid the method artefact of "model overfitting", meaning that constraints closer to the leaves can lead to overestimation of deeper nodes.
To minimize movement artefacts, the head of the subject was firmly fixed with cushions.
They were fixed with tape on a smooth table to prevent movement artefacts due to the electrical stimulation, the lower limbs gently stretched to make it easier to measure distances between proximal and distal points of stimulation.
Reconstruction parameters, including smoothing (1), ring artefacts reduction (4), and beam-hardening correction (30%), were fixed for all the samples.
Hence, our next analysis was to determine if sequence artefacts were also present in our cohort of recently fixed samples.
Only the extent of some artefacts was higher in the dried tissue than in the fixed material.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com