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Transcriptionally, this induction was associated with a fivefold increase in the activity of the FLO11 gene, an essential gene for pseudohyphal growth [ 20].
Addition of amino acids to nitrogen-deprived yeast cells triggers rapid changes in multiple targets of the PKA pathway, the most rapid being a fivefold increase in the activity of the trehalase enzyme due to post-translational phosphorylation by PKA.
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Cells treated with 40 μM SMIP001 and 004 from 24 to 72 h showed a three- to fivefold increase in the amount of mono and oligonucleosomes, thus confirming the apoptosis-inducing activity of SMIPs.
A431 parental cells were likewise sensitive to the pro-apoptotic effects of Ctx (up to a fivefold increase in the presence of 100 μg ml−1 Ctx) whereas they remained mostly insensitive to any pro-apoptotic activity of PD173074.
The reports showed a fivefold increase in the number of stop-and-frisks from 2002 to last year, with more than half of them involving black residents.
Even a fivefold increase in the price of raw uranium oxide has little impact on the price of nuclear power.
There was almost a fivefold increase in the number of laparoscopic myomectomies performed in 2016 compared to 2004 (Fig. 1).
One CBC investigation found a fivefold increase in the number of domestic violence cases reported by on-base military police, circa 2008.
Detection of a more modest 20% reduction required a fivefold increase in the number of reviewed records.
The laws have contributed to a fivefold increase in the state prison population since 1973.
There were 508,540 street stops all last year, a fivefold increase in the number from 2002.
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