In the brain, five times higher levels for AKβ-BA (4) compared to the nonformulated extract were determined 8 h after oral administration [114].
A higher initial amount of HABO resulted in two times higher level of soluble P concentration observed even at the end of the first batch cycle.
Four of the selected clones, that is: the transcription factor PPARG [19], adiponectin [20], GLUT 4 [21], and FABP4 [22], were confirmed to be present at more than two times higher level in the irradiated cells relative to the control cells.
At early puberty, two to three times higher level of superoxide anion was detected in males compared with females (p = 0.05).
Similarly, the expression of a recombinant EPO fusion (rhEPOFc) using the same magICON® expression system resulted in the generation of a chimeric recombinant hormone accompanied by a five to ten times higher level of free Fc [ 35, 36].
Ex vivo biodistribution studies with [11C]prucalopride in rats showed very low levels of radioactivity in brain (maximal 0.13% ID·g−1) and ten times higher levels in certain peripheral tissues.
In a former study by[33], the same sludge obtained from the same manufacturing area as in this study, demonstrated three to six times higher levels of EROD activity in the digested sludge than in the incoming flux[33].
In addition the following observations are of relevance: Five to eight times higher levels have been found at locations, where people had been exposed to PFOA contaminated drinking water indicating accumulation in the blood compartment [100, 101].
In addition, Finkelstein's group found that black-footed albatrosses, whose range extends from the West Coast of North America to Hawaii, had three to four times higher levels of PCBs, DDT, and mercury than the Laysan albatrosses, which forage near Alaska and the Aleutian Islands, perhaps indicating higher levels in the black-footed's domain.
Tumour epithelial cells contained about two times higher levels of TGF-beta2 and TGF-beta3 mRNA than normal epithelial cells.
