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To test this, we measured activation of the same five signaling proteins following stimulation with the PKC agonist prostratin and the histone deacetylase (HDAC) inhibitor SAHA, alone and in combination.
In addition to signaling pathways in cancer cells, the following five signaling networks were thus identified: MAPK, Calcium, Jak-STAT, Wnt and apoptosis.
For illustration and to put our hypothesis to the test five signaling systems have been evaluated: The Transpath [33] kinase network which was already analyzed in [17] for other properties and some recent canonical signaling networks [34] [37] retrieved from the Science STKE database [38].
Second, the dlk-1 pathway consists of five signaling molecules providing numerous points where regulation might occur.
Our model was based on the quantitative measurements of five signaling proteins that are activated downstream of the EGFR and are known to mediate key biophysical events of motility.
For further mechanistic insights, we have informatically identified the key links that connect miR-193a-3p miR-193a-3p miR-193a-3p genes (SRSF2, PLAU and HIC2) to the fiviasignaling pathrees and therefofe the chemoresitsantargetotype of BCa cells.
Similar(48)
At least two signaling pathways regulate filamentation.
(B) Mutational effects in the two signaling motif regions.
We have investigated how four signaling molecules contribute to chemotaxis.
Superinduction of IL-10 in macrophages requires two signaling cascades.
Intracellular zinc signaling consists of two signaling pathways.
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