The linear component of the fitting signal may arise from a second population of pHLIP-FIRE, in which some other mechanism is involved, such as nonspecific endocytotic uptake of the constructs, producing slow kinetics.
For model fitting, signal change in contralateral V5/MT+ and V1 regions of interest in controls were averaged and normalized, such that the sum of all points was equal to zero.
The T2 relaxation times of the water and CH2 resonances for each participant were calculated from the data by monoexponential fitting of signal intensity vs the six echo times, the signals at 35 ms were then corrected for T2 decay and the fat fraction was calculated as a percentage of the total signal from that volume [ 25].
In this article, it was shown that how the fitting of signal strength data series used in multivariate time series may present advantages compared with other signal propagation models.
In the static one, the weights are computed in a dedicated training phase, in which four algorithms (Fourier transform and quasi-harmonic fitting of signal denoised with Hilbert-Huang Transform, Hilbert Vibration decomposition, and Wavelet Packet decomposition) have been used to estimate the known imbalance of car wheels.
Then, approximate carrier frequencies are determined for successive time blocks by fitting theoretical signal spectra to the discrete Fourier transforms of the voltage variation in successive blocks (Lipa and Tyler, 1979).
To achieve robust fitting high signal-to-noise is required; therefore, a sufficient quantity of sample must be collected [ 37, 39].
In short, these methods are based on the selective 1D directed-COSY experiment (Pham et al. 2002, 2004) and provide coupling constants through fitting of signal intensities measured in a series of experiments.
Apparent diffusion coefficient values (ADC, 10-6 mm/sec) were calculated using Levenberg-Marquardt mono-exponential fitting with signal intensities from: (i) all b-values (0, 50, 100, 300, 600, and 1000 sec/mm, 'ADC0-1000') and (ii) b-values ≥100 sec/mm (100, 300, 600, and 1000 sec/mm, 'ADC100-1000') on a voxel-by-voxel basis.
