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We checked diagnostic plots (e.g., residual versus fitted plots) for potential outliers and data trends.

Graphs show sensorgrams (left panels) and fitted plot (right panels).

Homoscedasticity and normality of residuals were visually checked using residuals versus fitted plots and QQ plots.

The corresponding experimental points and fitted plot are presented in Figure 3d.

Graphs show sensorgrams (top panels) and fitted plot of equilibrium binding response (bottom panels).

Sensorgrams (top panel) and fitted plots (bottom panels) for a series of concentrations of Lrp6P1E1P2E2 are presented.

The residuals were normally distributed and the residual vs. fitted plot showed no evidence of non-linearity or heteroscedasticity.

Based on the fitted plots, we found cut points for each covariable that defined categories such that the OR within each category was approximately constant.

SPR sensorgrams (left panels) and fitted plots of equilibrium binding response (right panels; 1 1 Langmuir binding model) against a series of concentrations of Fz4CRD are shown.

Sensorgrams (top panel) and fitted plots of equilibrium binding response (bottom panels) for a series of concentrations of Fz4CRD are shown.

This is demonstrated in fig 2 which shows the fitted plots of the cubic equations for the unadjusted rate of decline for all three measures.