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To be fair, this has been a campaigning issue for cyclists for so long that all kind of initiatives have been tried: better training for drivers; education for cyclists; and even the fitting of additional mirrors on goods vehicles in an attempt to mitigate the driver's blind spot.
Fitting of additional parameters would not give a unique fit.
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However, the measured τ2 component (median values: blue τ2 = 4120 ps, green τ2 = 3594 ps) is almost a factor of two longer than that observed in the cited previous work, which may be attributed to many differences including species, tissue type, decay fitting procedure, presence of additional fluorescent species or in vivo versus ex vivo measurement.
Identifying the parameter set that is more likely to be the correct one requires simultaneous fitting to additional time-series, resulting from more than one set of experiments.
Third, a so-called F test was performed to assess the significance of the effect of additional fitting parameters on the fit residual.
To explore this issue fully will require a more sophisticated model, novel fitting approaches, and a collection of additional experiments.
Additional fitting of the structural equation models used Mx Maximum Likelihood Structural Equation Modeling software (version 32; Virginia Commonwealth University).
Additional fitting of the appendix data increases these estimates (best estimate 100, 95% prediction interval 10 2,600) but remains lower than previous projections.
Even with the additional fitting of the appendix data (which estimates a higher prevalence of asymptomatic infection in the population than would be predicted by fitting the model to the vCJD case data alone), the best fitting model estimates just 100 future cases with an upper limit of the 95% prediction interval of 2,500 cases.
Figure 4 Example of in situ extractions of fitting parameters and additional calculated parameters.
An alternative solution may consist in the use of additional constrains in the fitting procedure such as extending the layer width in case 'positive' attenuation is found.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com