Identification of coherent gene expression modules and of chromatin states fitting these modules demonstrates the complexity and dynamic nature of hPTM combinations during adipogenesis.
The ligand fit module [ 27] from GLIDE software was utilized to execute the molecular docking analysis, based on shape-based searching and Monte Carlo methods.
Liu and coworker managed to synthesize the 12 peptides out of 29 that were shown to have successfully docked into ICL crystal structure using Ligand Fit module of Discovery Studio 2.1 software (PDB id 1F8M) and one of the peptides has obtained as high as IC50 of 126 μM in bioassay [ 44].
Data were acquired and analyzed with Xcalibur 1.4 (San Jose, CA, USA), and regression analyses were performed with PRISM (version 5.0d) GraphPad software (La Jolla, CA, USA) using the nonlinear curve-fitting module with an estimation of the goodness of fit.
Although, on the flip side, the very large-of-wrist might manage to fit five modules.
The in silico docking was done using Schrödinger software package and its Induced Fit Docking module (Induced Fit Docking protocol 2013-2, Glide version 5.9, Prime version 3.2, Schrödinger, LLC, New York, NY, 2013).
The company also constructs mobile plants that are built in modules fitting into standard shipping containers and can be flown, trucked or shipped to remote locations around the world.
This is no ordinary space tourism company, Excalibur Almaz plans to launch the first private space station and, by fitting its habitation modules with engines, to support expeditions around the Moon and even beyond.
During a crux scene in Apollo 13, the engineers in Houston realize they have to somehow fit the Command Module's square carbon dioxide filter in the Lunar Module's round receptacles if they want everyone to keep breathing.
