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Gender differences were tested by fitting interactions.
Proportionality assumptions were determined both visually and by fitting interactions with the log of survival time.
In secondary analysis, similar models were fitted for remission definitions 2 and 3. Effect modification was systematically explored by fitting interactions between remission variables and confounders in multivariable models.
Model 3 was extended by fitting interactions (one at a time) between the socioeconomic variables (wealth and education) and gender and place of residence.
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As the predictions are compared to each other, it is obvious that the cubic-plus-association (CPA) equation of state (EOS) performs very well in all properties with a test fitting interaction parameter.
As exploratory analyses, the role of genotypic effects across various high-risk subgroups was examined both with stratified analyses and by fitting interaction terms into the regression models.
Effect modification by sex was explored by fitting interaction terms into the full model.
Before carrying out specific subgroup analysis, we will identify differential effects by fitting interaction terms.
Effect modification by sex was examined in stratified analyses as well as by fitting interaction terms.
Then, fitting interaction effects as random effects becomes essential, to allow the effects' constants that are derived from small subclasses to be regressed towards the population mean.
First, we examined effect modification by age, prior coronary heart disease, and smoking status by fitting interaction terms in the single pollutant models.
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