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The responses studied (Yi) were cumulative percentage released after 2 h (Q%2h), 6 h (Q%6h), 12 h (Q%12h) and regression coefficient of release data fitted to zero order equation (RSQzero), for Y1, Y2, Y3, and Y4, respectively.
In order to investigate the kinetic modeling of drug release from NPs, the dissolution profiles were fitted to zero order (Q = k 0·t); first order (ln (100 - Q) = ln Q 0 - k 1·t), Higuchi (Q = k H·t 1/2), and Korsmeyer-Peppas models [18].
In vitro release data was fitted to zero order, first order and Higuchi release models 32, 33.
The 95% confidence intervals were overlapping for all intercepts (fitted to zero), but for the slope, the confidence interval for diet AR did not overlap with those of the remaining groups.
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