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The gray circles represent the actual measured activity in the ROI, the red circles the image-derived input function or the ex vivo-derived input function from whole blood samples, and corresponding lines represents the fitted input curves.
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In each step of the search, we use parametric bootstraps and the Mahalanobis distance to estimate how well a proposed set of parameters fits input data.
Figure 8 visualizes fit input and results.
A couple of German researchers hacked the Wii Fit input device to work with Google Earth and other oddball applications.
Inverse UQ always captures the uncertainty of its estimates rather than merely determining point estimates of the best-fit input parameters.
We limited the fit input to 20 < x < 150 m, as packet loss occurred at x < 150 m and small distances are inaccurate as the transmitter was not exactly positioned in intersection centers.
The fit input values are form the regular shaped (≈90° and w t ≈ w r ) intersections with buildings at each corner: intersection 2, 3, 10, 11, and 20, with w r being 21, 21, 23, 26 and 30 m, respectively, and intersection 2 and 3 having i s = 1.
A simplified kinetic method (SKM) is advocated [ 96], assuming a uniform input function, based on fitting the input function of control patients with a triexponential decay function.
Both estimations fit their input data equally well; applied to new inputs of the same form (specifically, the same degree of uncertainty), they would give equally accurate predictions.
A combination of blood samples taken at intermediate and late times reduces the median RMS norm values of the estimated input functions to only 10% greater than those obtained by directly fitting the input function model (Equation 4) to the arterial TACs obtained by continual blood sampling.
(C ) Sigmoid fits from input strength normalization curves for three example slices reveal the need for a normalization procedure to compare physiologically equivalent input intensities among experiments.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com