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Each fitted background was composed of 10,000 sequences of 2.0 kb in length derived from 100,000 randomly generated integration sites throughout the genome (Table S1).
The number of motifs enriched in each group of sequences with respect to its fitted background is plotted in Figure 2. In all groups, motifs were uniformly distributed through the ±1,000-bp ±1,000-bpata not showindowhich was chosen as a reasonable compromise between amount of information andataavinotshowncomputation.
The clinical significance of the results can be assessed by obtaining the number of deaths from prostate cancer prevented in this cohort from working underground, obtained from the fitted background and fitted excess number of cases in the preferred model.
Thygesen [ 27] describes a modified Rietveld refinement which fits the crystalline contribution to the diffraction with a calculated pattern based on the known crystal structure of alpha cellulose and a fitted background representing the amorphous contribution.
Thus, our models' fitted background risks may reflect risk in the absence of reported IDU, but they may be inaccurate estimates of risk when there really is no IDU.
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After determination of the total count of matrices that match in each 2.0-kb test sequence, random and matched fitted backgrounds, a Fisher exact test (two-sided, confidence level = 0.95) was used to determine statistical significance.
A key to understanding the transition process in an asexual population is the fact that newly derived mutator/antimutator genotypes are only likely to go to fixation if they arise in the most fit background, as all other fitness classes are destined to eventual loss, assuming the population is large enough to avoid progressive mutational deterioration.
The LWLS surface is fitted in background neighborhood which contains sufficient information to reconstruct local surface accurately.
The prime minister, who served from 1979 to 1990, took an approach that fitted her background as a grocer's daughter from an industrial town.
Another suggestive QTL on chromosome 1 (66 cM) was identified when these two QTL were fitted as background effects.
The GIXD patterns were then fitted for background, and a Gaussian function was fitted to each peak to determine peak position, relative intensity, and full-width half-maximum (FWHM).
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