Fitting this hypothesis, expression of CD95 correlated with the expression of the known EMT marker genes VIM, FN1, SNAI2 and S100A4 in the TCGA data set (Supplementary Figure S3).
More precisely, if a null hypothesis is postulated in terms of an evolutionary process acting on a population or a group of populations, then predictions about how different data would fit this hypothesis can be compared with real, observed patterns.
Actually, the difference current was negative ( Fig. 2A), and fitting this hypothesis would lead to a negative estimate of PCl≈ 0.2 pl/s for nAChRs.
Indeed, we provide experimental evidence in-vitro, in-vivo and in clinical melanoma specimens that previously known tumor-suppressive and tumor-promoting miRNAs fit this hypothesis.
A tree manually rearranged to fit this hypothesis received p-values < 0.001 in both AU and WSH tests.
To check whether our data fit this hypothesis, we shuffled protospacers across the individual metagenomes, so that the number of protospacers in a given individual remained unchanged.
Based on the statistical analysis of a tree manually rearranged to fit this hypothesis, this option cannot be clearly ruled out (p = 0.017 and 0.05 with the AU and WSH tests, respectively).
Hence, the stronger overexpression phenotypes obtained with A.m.H in the wing nicely fit this hypothesis because of the missing acidic stretch in the Apis H orthologue. Notch is required for the correct development of a multitude of tissues owing to its involvement in cell growth, cell death and cell differentiation [ 1, 2, 35].
