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A user would set up the system's software by filling out a profile on what Mr. Kriger calls the "fitness screen".
Drug sensitivity data were obtained from the heterozygous fitness screen of Hillenmeyer et al. (2008).
In C. albicans a fitness screen of nearly 3000 heterozygous mutants lacking one copy of each gene, termed a haploinsufficiency screen, was used to investigate the mode of action of novel compounds with potential antifungal activity (Xu et al., 2007).
In the case of the SEA complex, the link has been inferred from genome-wide pairwise fitness screen data (Beck et al. 1999; Dokudovskaya et al. 2011; Schmidt et al. 1998).
The correlates of obesity in Chinese children are similar to those reported in studies conducted in other countries, including family background (family income, parent education, parent weight status), birth weight, breastfeeding, physical activity, physical fitness, screen time, diet, access to physical activity and healthy foods, and regions of residence [ 28, 29, 40- 42].
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In the case of a highly studied organism like the budding yeast, S. cerevisiae, microarray expression data for the entire genome under a variety of perturbations is available [13], and several global rapamycin fitness screens have been carried out [14] [17].
These include experimental limitations, such as the poor sensitivity of fitness screens (32) and the narrow range of cultivation condition tested (generally complex medium) (33).
16 17 Children with increased motor impairment are known to perform poorly in sport and exercise fitness screening tests, 18 19 but the physiological and perceptual responses limiting exercise performance have not been explored in these individuals.
Thus, mediated effect could be controlled by the simultaneous use of the RHR together with other variables (e.g. general obesity, abdominal obesity, low cardiorespiratory fitness) to screen adolescents at an increased metabolic risk in further studies [ 27].
Unless, that is, you read the press releases, which herald the library, fitness center, screening room and antique bar with personal bottle lockers in Trufflesprivé, the members-only club off the lobby; the cobblestone courtyard "reminiscent of old New York"; and the sundeck on the roof, which is meant to suggest an Amagansett summer house.
Some laboratories have pioneered an alternative approach in which cells are infected en masse with pools of shRNA vectors and the abundance of individual shRNA is monitored over time as a reflection of their effect on cellular fitness (pooled screens) [ 45- 50].
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