Sentence examples for fitness pathways from inspiring English sources

However, it significantly extends this work by providing a general analytic solution for determining the relative efficiency of mutator pathways, compared to non-mutator pathways, for fitness pathways involving increased fitness of malignant lineages and their precursors, as well as providing an analysis of negative clonal selection in the presence of tumor evolution.

Furthermore, we find that in all these simulations modular, high fitness pathways first emerge in the population after only few generations (19 generations for the simulation shown in Figure 2).

In all the alleles in the population, there was phenotypic convergence as to the benefit of rpoS mutations, but the combination of different alleles with different other mutations contributes to the complexity of fitness pathways in the evolving population.

Thus, based on analysis of these pathways in combination (together with the constant fitness pathway previously analyzed [15]), any conceivable fitness landscape could be analyzed.

Throughout the evolutionary simulations pathway fitness, and various pathway properties are recorded.

Population genetic simulations were used to understand the combined effect of mutation rate, recombination rate, population size, and fitness on pathway evolution.

As discussed in Results and discussion section the ratio between the relevant rates of these two routes affect modularity but not fitness and pathway size (see Additional File 3).

Once arisen, the probability that such functional modules will be maintained will depend on the frequency of mutations leading to formation of interactions among proteins already participating in the pathway and the fitness of resulting pathways.

This term decreases as the number of steps in a pathway increases (n larger), implying that halving concentration has a large effect on fitness in short pathways, but only a minor fitness effect in long pathways (fig. 3).

I also studied the effect of individual haplotype fitnesses on pathway accessibility.

Thus, a plethora of factors could influence also offspring fitness via epigenetic pathways.