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In my view Virtuagym has the best chance to become the electronic health record of the fitness industry and we're already partnering with large industry players such as Life Fitness, Matrix and Keiser to make this a reality".
Our generic data transformation procedure is built on a decomposition model for the double-mutant fitness matrix.
Moreover, a simple preprocessing of the fitness matrix could further enhance the discrimination power of the epistatic miniarray profiling (E-MAP) dataset.
The application of a scoring function individually to each of the gene pairs (a,b) transformed the double-mutant fitness matrix W into a score matrix S, which preserves the dimensionality of the original fitness matrix, but has model residuals as its entries instead of the double-mutant fitness measurements.
To select increasingly large subsets of non-missing and non-diagonal mutation pairs from the double-mutant fitness matrix W, we adapted the floating search method of Pudil et al. [17].
However, when considering the whole range of specificity, the original fitness matrix showed relatively good detection power, especially in the negative interaction categories (see the partial and overall AUC values in Table 2).
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The present study demonstrated that the double-mutant fitness matrices, obtained from the large-scale quantitative interaction screens, alone contain sufficient information according to which it is possible to distinguish gene pairs encoding both positive and negative classes of interactions.
Under the BDM incompatibility model, two distinct fitness matrices are possible.
Selection is determined by the fitness matrices w H ij and w P ij.
Random assignment of 207 pairs to each of two possible BDM incompatibility fitness matrices.
DOI: http://dx.doi.org/10.7554/eLife.02535.017 10.7554/eLiFigure35 figuregure 5—figure supplement 1. Different fitness matrices associated with selection against hybrid incompatibilities.
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