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This may lead to a cascade of reduced fitness, generation upon generation.
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The GroupFix strategy converged essentially after about 100,000 generations, when it had reached 99.5% of the fitness from generation one million compared to the fitness from generation one (itself the best of 50 randomly generated legal solutions).
Fitness at generation 200 thus implied a rise from generation 80 of about four doublings per hour.
We generally see an increase of mean population fitness with generation (for all trials, mean population fitness is increased by 2.5 times in five generations), but the outcome of the individual five-generation trials vary considerably.
Scaled up to the entire haploid genome, this would imply a 2.6% decline in fitness per generation in homozygous females, and a 3.9% decline per generation in homozygous males.
The experiment continues for five generations, and the main result is the growth of mean population fitness with generation.
Because of this added complexity, it may be necessary to allow more generations than five; however, we usually see a consistent increase in fitness with generation.
Concepts reviewed here include fitness, mutant generation, competition, selection, sequence space and the theoretical origins of quasispecies.
Finally, we present some of our former studies involving pathogenic taxa where mutation and recombination played crucial roles in the recovery of pathogenic fitness, the generation of interspecific genetic diversity, or the design of centralized vaccines.
In all cases, we have seen an increase of fitness with generation.
Open image in new window Figure 6 Average fitness of generation and best of them.
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