Sentence examples for fitness defects from inspiring English sources

Strains expressing mCherry showed no fitness defects in vitro or in macrophages.

Broth culture prfA*-associated fitness defects were alleviated when glycerol was provided as the principal carbon source; under these conditions prfA* mutants exhibited a competitive advantage over wild type strains.

Based on the reports of functional overlap of SigB and PrfA in regulation of L. monocytogenes gene expression [40], [53] [60] and the fact that SigB is one of the most characterized stress response regulators of L. monocytogenes [52], it seemed logical to investigate whether the stress-associated fitness defects exhibited by the prfA* mutants were related to alterations in SigB function.

Noticeably, all displayed fitness defects in the presence of MMS.

It is interesting that both mutations that confer fitness defects individually are in coding regions.

Mutations in DAM1 show synthetic fitness defects with mutations in RTT103.

Moreover, the activation of several oncogenic pathways failed to alleviate the fitness defect induced by aneuploidy.

The fitness defect of K103N + L100I relative to K103N was completely compensated for by the addition of the nucleoside resistance mutation L74V.

Next, we constructed a ybp2Δmad2Δ double mutant in our background (YPH499) to assess the double mutant for a more subtle synthetic fitness defect.

The rrnD-rrnE inversion is interesting because the same inversion in E. coli is rapidly overgrown in culture by revertants, suggesting that it causes a fitness defect [30].

Negative interactions correspond to a more severe fitness defect in the double mutant than expected from the fitness of single mutants (such expected fitness can be defined in different ways, see [18], [19] and below).