Your English writing platform
Discover LudwigSuggestions(1)
Exact(6)
We provide evidence to suggest that the contextual application of many FiT structures is suboptimal, assuming both investors and policymakers are at least moderately risk averse.
In order to fit structures consistently, peptides forming dimers were labeled such that similar molecules were given the same chain identifier (ID).
Two induced fit models, model 3 and model 5 of the induced fit structures showed much improved enrichment (Table 2; table S5 in the Supporting Information).
Therefore, this allows us to flexibly fit structures using a coarse-grained model which is computationally more efficient than using an all atom model.
Generally, where a file contains multiple models and alternative occupancies, a program (e.g. to calculate solvent accessibility or to fit structures) requires a single set of coordinates and none of the other information that comes with the coordinates.
Although ultimately neither the homology model nor induced fit structures outperform the parent PI3K δ structure, 2WXL; this induced fit modeling approach is clearly useful for the development of homology models with good ability to discriminate active compounds from compounds in the decoy set.
Similar(54)
The "fit" structure of "c" epitope may have some atoms in energetically unfavorable positions or amino acids with unfit torsions.
Based on chemical modification and nuclease sensitivity studies, Wassarman and Steitz created a best fit structure for 7SK [57SK
The results suggest certain internal loops may be poised for molecular recognition by induced fit, structure capture, adaptive recognition, or all of them.
Local analysis of bearing stresses and initiation of failure at fastener-hole location in interference-fit structures is crucial for achieving their optimal structural design and reliable service conditions.
But in 1897 The New York Tribune boomed that it was "one of the most sumptuously fitted structures" anywhere, adding, "few of the Old World places... can compare with its richness of architectural fibre and interior finish".
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com