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Studies comparing gFOBT and FIT in screening populations have shown that the former has higher sensitivity for both invasive cancers and advanced adenomas with comparable specificity.
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The objectives of this study, therefore, were to: (i) rigorously evaluate participant uptake of FIT testing in a population that received either a one-sample FIT kit (1-FIT) or a two-sample FIT kit (2-FIT) and (ii) understand how participant uptake of FIT screening (1-FIT vs. 2-FIT) may vary by age, sex, and receipt of prior CRC screening.
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We compared our Weibull survival functions with a Kaplan-Meier survival function, and found good fit in control and screened groups across all studies.
This study will also provide information on interval cancers in FIT based screening, in a third round of biannual pilot screening.
In addition, detection rates of advanced neoplasia (CRC and advanced adenomas) were higher in FIT screening than in guiac-based screening: 2.4% and 5.5% versus 1.1%and1.2%2%.
The estimation of sensitivity and specificity of FIT in population-based screening is hampered by the fact that numerous tests are available with heterogeneous performance characteristics, and various approaches have been taken to estimate sensitivity, a criticism that has been made previously (Burch et al, 2007).
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