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The primary independent variable was FIT group (1-FIT vs. 2-FIT).
FIT group (1-FIT vs. 2-FIT) was the primary independent variable.
The final Cox regression model included: (i) FIT group [1-FIT (reference group) vs. 2-FIT], (ii) age [<60 years (reference group) vs. >60 years], (iii) sex [male (reference group) vs. female], and (iv) prior CRC screening [no (reference group) vs. yes].
Additionally, the moderate and high fit groupings differed significantly from the low fit group for weight and BMI.
Of particular importance, large clinically meaningful reductions in disease risk are achieved when moving from the least active (or low fitness) group to a moderately active (fit) group.
2 5 Evidence suggests a strong inverse mortality gradient across fitness groups, with a 50% lower death rate for the highly fit group, 6 a better lipid profile and a decreased incidence of coronary heart disease.
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Of the 3121 members eligible for randomization, 1559 were assigned to the 1-FIT group (receiving one FIT kit), whereas 1562 were assigned to the 2-FIT group (receiving two FIT kits).
Of the remaining population, we mailed FIT kits to the homes of 1540 members of the 1-FIT group and 1541 members of the 2-FIT group.
Compared with the 1-FIT group, the 2-FIT group was found to be less likely to complete the FIT on both unadjusted [hazard ratio (HR)=0.87; 95% confidence interval (CI =0.78 0.97; P=0.012] and adjusted (HR=0.87; 95% CI=0.78 0.97; P=0.010) analyses.
The less-fit group had increases in those same metabolites of about 50 percent.
What they found was that after 10 minutes of treadmill jogging or stationary-bicycle riding, the healthy adults showed enormous changes in the metabolites within their bloodstream, as did the less-fit group, although to a lesser degree.
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