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As seen with certain H5N1 viruses, poultry can serve as the intermediate host between wild birds and humans, although these viruses can remain fit for replication in wild birds.
Although the M184V virus would exhibit hypersusceptibility to TDF or AZT and would be less fit for replication, a regimen based on one active NRTI and an NNRTI, given the low barrier to resistance of the NNRTI, runs the risk of treatment failure.
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A second line of support for this idea comes from the observations measuring the number of hematopoetic stem cells in mice, cats or humans [ 5] and surprisingly the number of these stem cells increases with age (selection of more fit cells for replication) but the ability to transplant these cells into a recipient declines with age (selection of less fit for differentiation).
Our studies strongly suggest that the internal genes of diverse H9-lineage viruses are fit (to various degrees) for replication in mammalian models and human cells.
A linear model including effects for replication and genotype was fit to the log ratio data from each probe to identify the subset of probes that diagnostically detected homoeolog-specific expression.
One region for replication was also taken from the analysis fitting a general model with residual outliers included.
A linear model with fixed effects for replication, endotoxin dose, time, and interaction between dose and time were fit to the expression data for each gene using the R package limma [ 40, 41].
"We were looking for replication," she said.
He added that his study was "crying out for replication".
The caption read, "The perfect setting for replication".
A New Etiquette for Replication.
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CEO of Professional Science Editing for Scientists @ prosciediting.com