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OPTIMA was compared against the state-of-the-art algorithms Gentig v.2 (alignment module) [ 16, 17, 24], SOMA v.2 [ 10] and Valouev's likelihood-based fit alignment [ 13] for glocally aligning the simulated maps over their respective in silico reference genomes.
The ligand-based (LB) studies were performed based on the lower energy conformations employing atom fit alignment rule.
The best predictive CoMFA model with atom fit alignment resulted in cross-validated r2 value of 0.553, noncross-validated r2 value of 0.908 and standard error of estimate 0.187.
Using the multipoint registration and best fit alignment command, "DataWaxRP" was registered to "DataModel&WaxRP" and "DataWaxManual" to "DataModel&WaxManual," where the polished surface of the wax denture was set as the common area.
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The 3-dimensional accuracy determined by best-fit alignment method and volumetric changes were identified by volumetric measurements.
The best CoMFA model using atom-fit alignment approach with the bound conformation of compound 21 as the template yielded the steric parameter as a major contributor (nearly 70%) to the observed variations in biological activity.
The adjacent gingival tissue was deleted along the margin of the clinical crown to allow accurate best-fit alignment of the crowns.
The ClustalW algorithm [31] and the Homology module of InsightII (version 2000 Accelrys San Diego CA) were applied in sequence alignment, and the best-fit alignment was obtained based on the Blosum scoring matrix [32] and previous alignments [16].
First, the best-fit alignments between a scaffold and the set of input reference genomes are calculated using BLAST so that the predicted reference genome for the scaffold can be obtained.
Many potential acquisitions don't consummate because the perceived cultural fit and/or alignment on the future vision doesn't completely align.
This paper takes a contingency-based perspective of ERP adoption, assessing the fit or alignment between ERP functionality and a MTO production strategy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com