Exact(7)
Hence, we tested whether TMD hydrophobicity has an impact on GDAP1 fission function.
Positively charged aa flanking the TMD on the cytosolic side control both mitochondrial targeting and the fission function of GDAP1.
TMD sequence, length, and high hydrophobicity do not influence GDAP1 fission function if MOM targeting is maintained.
Furthermore, our data show that signals that determine the targeting of GDAP1 to mitochondria as part of the TA are also crucial for the fission function of GDAP1.
This study was aimed at determining the precise topology of GDAP1, the motifs involved in MOM targeting and integration, and the relationship between TA structure and the fission function of the protein.
Furthermore, while dynamin-2 functions during endocytosis, more recent evidence has emerged for functions at other stages of membrane trafficking giving rise to the possibility of a more general fission function, similar to Vps1.
Similar(53)
The explanation is rendered by David Macaulay, the writer and artist who showed adults and children alike "The Way Things Work" in his 1988 gem of the same name, which revealed how things from toilet tanks to nuclear fission functioned.
Now, it only takes them an hour or so to get their first Fission functions to run.
Third, concerning the inhibition of endosomal acidification, it is unknown whether V-ATPase is activated in the absence of fission; namely, it is possible that fission functions as a switch that triggers V-ATPase activation.
Mitochondrial fission functions downstream of Parkin recruitment to promote mitophagy.
Thus, Drosophila MUL1 has a mild pro-fission function, as with mammalian MUL1 (Braschi et al., 2009).
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